Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and tempol
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چکیده
منابع مشابه
Inhibition of human sperm respiration by 4-hydroperoxycyclophosphamide and protection by mesna and WR-1065.
OBJECTIVE To determine the effect of 4-hydroperoxycyclophosphamide (4OOH-CP) on the respiration of human sperm, and investigate the protective properties of mesna and WR-1065. SETTING SUNY Upstate Medical University, Syracuse, NY. PATIENT(S) Men (n = 12) visited the Andrology Department for fertility evaluation. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Sperm respiration. RESULT(S...
متن کاملEffect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats
Objective(s): Neuroinflammation and oxidative stress play a key role in pathogenesis of Parkinson’s disease (PD). In the present study we investigated the effect of reactive oxygen species (ROS) scavenger WR-1065 on catalepsy and cerebrospinal fluid (CSF) level of interleukin 6(IL-6) and striatum superoxide dismutase (SOD) activity in 6-hydroxydopamine (6-OHDA) induced experimental model of PD...
متن کاملDetermination of WR-1065 and WR-33278 by liquid chromatography with electrochemical detection.
A liquid chromatographic method using electrochemical detection is presented for measuring the thiol WR-1065 12-(3-aminopropylamino) ethanethiol] and its symmetrical disulfide WR-33278 [NH2(CH2)3NHCH2CH2S]2. WR- 1065 is the active, radioprotective drug derived from the phosphorothioate pro-drug WR-2721 (amifostine). External standard curves for both compounds were linear over the range of 40-20...
متن کاملLiposomal Antioxidants for Protection against Oxidant-Induced Damage
Reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide, and hydroxyl radical, can be formed as normal products of aerobic metabolism and can be produced at elevated rates under pathophysiological conditions. Overproduction and/or insufficient removal of ROS result in significant damage to cell structure and functions. In vitro studies showed that antioxidants, when applied...
متن کاملProtection of cadmium chloride induced DNA damage by Lamiaceae plants.
OBJECTIVE To analyze the total phenolic content, DNA protecting and radical scavenging activity of ethanolic leaf extracts of three Lamiaceae plants, i.e. Anisomelos malabarica (A. malabarica), Leucas aspera (L. aspera) and Ocimum basilicum (O. basilicum). METHODS The total polyphenols and flavonoids were analyzed in the ethanolic leaf extracts of the lamiaceae plants. To determine the DNA pr...
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ژورنال
عنوان ژورنال: Environmental and Molecular Mutagenesis
سال: 2014
ISSN: 0893-6692
DOI: 10.1002/em.21872